This is a summary of our current understanding of the impact of the Chrome SameSite change that has been well-publicized, and is due to appear in Chrome 80 on February 417, 2020.
While this page discusses the direct implications of this change on the operation of the SP software, the fact is that the bulk of the concerns in most cases lie within the application space and are not going to be remedied by anything here. Nor can we provide any sort of yes/no or good/bad conclusion for anybody as to whether "their system is affected". That is going to depend entirely on the individual case and the only real answer is to test.
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